College football is American football played by teams of student athletes fielded by American . Two teams of 25 players attempted to score by kicking the ball into the opposing team's goal. Throwing or carrying .. The Big Game between Stanford and California is the oldest college football rivalry in the West. The first game. The college football season kicks off in full this weekend with Top 25 teams in action Thursday through Monday. The following is a list of historically significant college football games. Games included on this Games that may be significant only to a particular team's fan base should not be listed here. Game, Home, Visitor, Location, Final score, Notes . 0–6, Widely considered one of the greatest upsets in college football history.